Aug 30, 2017 drug drug interactions theophylline interacts with a wide variety of drugs. Levofloxacin and theophylline drug interactions ehealthme. Flexible plastic container do not admix with other drugs rx only description theophylline is structurally classified as a methylxanthine. Use of low doses of theophylline that give plasma concentrations of 5 to 10 mgl largely avoids side effects and drug interactions and makes it unnecessary to monitor plasma concentrations unless checking for compliance. Theophylline oral interactions with other medication. Theophylline definition of theophylline by the free. A colorless crystalline alkaloid, c7h8n4o2, derived from tea leaves or made synthetically, used as a bronchodilator primarily to. Adverse reactions and interactions with theophylline springerlink. Drugdrug interactions involving macrolides are typically attributed to mechanism. Patients receiving uniphyl theophylline anhydrous tablet tablets may pass an intact matrix tablet in the stool or via colostomy. Ge za lakner drug interactions table of contents preventable drugrelated morbidity pdrm important principles for physicians to consider when prescribing any drug adverse drug reactions adr adverse drug experience postmarket ade reports by top10 ranked classes of suspect drugs fda, 1995. Theophylline new perspectives for an old drug american. Theophylline elixophyllin, theo24 daviss drug guide. Theophylline drug interactions can alter the level of theophylline in your blood or make some drugs less effective, among other things.
Many drugs interact with theophylline by inhibiting or potentiating its metabolism by cyp1a2 see commonlyused drugs that interact with theophylline. Mechanism of action this drug acts by relaxing bronchial smooth muscle, causing bronchodilation and increasing vital capacity, which has been impaired by bronchospasm and air trapping. We have studied the interaction of erythromycin with theophylline. Dailymed theophylline anhydrous theophylline tablet.
Study of drugdrug interactions in the medication charts in medicine. Theophylline oral tablet is only available as a generic drug. A drug interaction on the level of absorption, as reported in the case of omeprazole plus itraconazole, was considered a priori to be. Theophylline is used to treat the symptoms of asthma or other lung conditions that block your airways, such as. It occurs as a white, odorless, crystalline powder with a bitter taste. Look up information on diseases, tests, and procedures. Efficacy is related to blood concentrations, which are determined mainly by hepatic metabolism that may be increased or decreased in several diseases and by concomitant drug therapy. From the safety viewpoint, the pharmacist has the legal duty to warn about potentially harmful drug interactions. G biopharmaceutical and pharmacokinetic drug interactions with theophylline. Compare theophylline costs and get a free theophylline coupon from a licensed canada pharmacy so you can save 5090% off all your medication prices. Drug information on aquaphyllin, asmalix, elixophyllin theophylline includes side effects, uses, drug interactions, dosage, drug pictures, overdose symptoms, and what to avoid. Theophylline is sometimes used to treat breathing problems in premature infants. The plasmatheophylline concentration is decreased in smokers, and by alcohol consumption. Theophylline definition of theophylline by the free dictionary.
As a clinically significant drug interaction could be exluded from our data, coadministration of ppi in therapeutically recommended doses does not require additional therapeutic drug monitoring of theophylline. Aminophylline is a salt of theophylline and releases free theophylline. It is noteworthy that when the drugs were used in combination the effects of. See what others have said about theophylline, including the effectiveness, ease of use and side effects. Drug interactions are reported among people who take levofloxacin and theophylline together. Pdf interactions between theophylline and salbutamol on. In this paper, we introduced an automatic computational. Differences in the halflife of theophylline are important because the toxic dose is close to the therapeutic dose. This medication is sometimes prescribed for other uses. Interaction between phenytoin and theophylline in healthy. The plasmatheophylline concentration is increased in heart failure, hepatic impairment, and in viral infections.
The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is. We use cookies to make interactions with our website easy and meaningful, to better understand the use of our services, and to tailor advertising. In general, maintaining peak serum theophylline concentrations between 10 and 15 mcgml will achieve most of the drugs potential therapeutic benefit while minimizing the risk of serious adverse events. Therapy with theophyllines should be administered cautiously in patients with impaired renal function. Theophylline 200, 400 and 800 mg in 5% dextrose injection, usp. This study is created by ehealthme based on reports of 26 people who take theophylline and alcohol from food and drug administration fda, and is updated regularly. She has been using salbutamol and fluticasonesalmeterol. Webmd provides information about interactions between theophylline oral and theophyllinestacrine. Furthermore, the reversal of the steroid resistance induced by oxidative stress suggests that theophylline may increase responsiveness to corticosteroids.
Review article drugfood interactions and role of pharmacist. Characterization of the mechanism of drugdrug interactions. The drug is metabolised in the liver by cytochrome p450 isoenzymes, principally cyp1a2, to demethylated and hydroxylated products. The numerous side effects associated with theophylline, drugdrug interactions and requirement for plasma monitoring limit the use of this drug. Pdf theophylline dimethyxanthine has been used to treat airway diseases for over 80 years. Aminophylline is a salt of theophylline and releases free theophylline afteradministration. Identifying drugdrug interaction ddi is an important topic for the development of safe pharmaceutical drugs and for the optimization of multidrug regimens for complex diseases such as cancer and hiv. Therapeutic consequences of drug interactions with theophylline.
Multiple drug interactions can occur, which can both increase and decrease the effects of theophylline. Additive cv and cns side effects with adrenergics sympathomimetic. A second infusion of theophylline was given after 9 days of treatment with 1 g erythromycin base daily, and the concentrations of. A drug interaction between zafirlukast and theophylline. There are 7 disease interactions with theophylline which include. Find information on theophylline elixophyllin, theo24 in daviss drug guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Identifying drug drug interaction ddi is an important topic for the development of safe pharmaceutical drugs and for the optimization of multidrug regimens for complex diseases such as cancer and hiv.
Theophylline is the generic name for the prescription drugs uniphyl in canada and theo24. It must be used regularly to prevent wheezing and shortness of breath. Theophylline, also known as 1,3dimethylxanthine, is a methylxanthine drug used in therapy for respiratory diseases such as chronic obstructive pulmonary disease copd and asthma under a variety of brand names. Clinical studies indicate that the drug does not interact with theophylline malmstrom,am j ther. We gave ten healthy volunteers theophylline as an intravenous loading dose 5 mgkg. Theophylline clearance can be reduced by erythromycin, and erythromycin exposure might be reduced by theophylline. This study is created by ehealthme based on reports of 186 people who take levofloxacin and theophylline from food and drug administration fda, and is updated regularly. See what others have said about theophylline, including. Theophylline fda prescribing information, side effects and uses. Additive cv and cns side effects with adrenergics sympathomi.
Adverse drug interaction involving pancuronium and aminophylline. Theophylline fda prescribing information, side effects. This means providing safe, effective, timely, and costconscious therapy. Copd home theophylline drug interactions more info on theophylline drug interactions interested in a discount on theophylline. This study is created by ehealthme based on reports of 186 people who take levofloxacin and theophylline from food and drug administration fda, and is. A second infusion of theophylline was given after 9 days of treatment with 1 g erythromycin base daily, and the concentrations of theophylline were determined. There have been about 150,000 publications on ddis in pubmed, which is a great resource for ddi studies.
Theophylline drug interactions among the drugs that can potentially interact with theophylline are alcohol, cimetidine, and certain antibiotics. Theophylline does not undergo any appreciable presystemic elimination, distributes freely into fatfree tissues and is extensively metabolized. All interactions with theophylline slophyllin, theodur coadministered drug dose of drug dose of theophylline effect on drug levels effect on theophylline levels. Theophylline uniphyl and theo24 side effects, dosage. Its used to treat airflow obstruction symptoms such as wheezing, shortness of breath, and chest.
All interactions with theophylline slophyllin, theodur coadministered drug dose of drug dose of theophylline effect on drug levels effect on theophylline levels potential clinical effects mechanism of interaction management. Lack of drug interaction between omeprazole, lansoprazole. Clinically significant drug interactions with theophylline. Theophylline is used to treat lung diseases such as asthma and copd bronchitis, emphysema. Calculate initial dosage using the following equation. Interactions between theophylline and salbutamol on cytokine release in. Find information on aminophylline in daviss drug guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Theophylline is given systemically orally as slowrelease preparations for chronic treatment and intravenously for acute exacerbations of asthma. As a member of the xanthine family, it bears structural and pharmacological similarity to theobromine and caffeine, and is readily found in nature, being. The plasma theophylline concentration is increased in heart failure, hepatic impairment, and in viral infections. Find patient medical information for theophylline oral on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. To reduce the risk of developing potentially dangerous drug interactions with theophylline, you should talk with your healthcare provider or pharmacist about any theophylline interactions that may apply to you.
Drugdrug interactions theophylline interacts with a wide variety of drugs. Theo24theophylline anhydrous extendedrelease capsules. It works in the airways by relaxing muscles, opening breathing passages. Before addition of a newly available drug in a patient receiving theophylline, the package insert of the new drug andor the medical literature should be consulted to determine if an interaction between the new drug and theophylline has been reported. At serum theophylline concentrations 20 mcgml, both the frequency and severity of adverse reactions increase. In vitro studies indicate that montelukast does not inhibit cyp450 enzymes. Ciprofloxacin causes large increases in theophylline concentrations erythromycin. Pharmacokinetic drug interactions with theophylline. Theophylline concentrations are increased by cimetidine, however, famotidine, nizatidine, and ranitidine do not appear to interact. The plasma theophylline concentration is decreased in smokers, and by alcohol consumption. Theophylline interactions learning article pharmaceutical journal. Use the search field above to look up prescription or otc drugs, and herbal supplements. Our free discountrx savings card can help you and your family save money on your prescriptions.
The pharmacokinetics of theophylline vary widely among similar patients and cannot be predicted by age, sex, body. Aquaphyllin, asmalix, elixophyllin theophylline uses. The effects reported were altered theophylline concentration, blunting of diuretic effect of furosemide and increased risk of qt interval prolongation respectively. The absence of an interaction does not necessarily mean no interactions exist. Alcohol affects body processes and interacts with many drugs.
Additionally, theophylline can interact with several drugs eg, benzodiazepines, propofol, ketamine, causing a decrease in efficacy of those drugs. You can reduce the risk of potentially harmful drug interactions and side effects with a little bit of. Smoking,barbiturates, carbamazepine, phenytoin, nevirapineand rifampinmayqmetabolism and may decrease effectiveness. Theophylline interactions learning article pharmaceutical. Dailymed theo24 theophylline anhydrous capsule, extended. Interactions between theophylline oral and theophyllines. Drug interactions are reported among people who take theophylline and alcohol together.
In this paper, we introduced an automatic computational method for the systematic. A colorless crystalline alkaloid, c7h8n4o2, derived from tea leaves or made synthetically, used as a bronchodilator primarily to treat asthma and chronic. Uniphyl theophylline anhydrous tablet tablets are not to be chewed or crushed because it may lead to a rapid release of theophylline with the potential for toxicity. Talk to your doctor about the possible risks of using this drug for your babys condition. Eds the use of sustained release theophylline in the treatment of chronic reversible airways obstruction, pp.
In addition, the plasma protein binding of theophylline may be significantly decreased in renal impairment, resulting in elevated free drug concentrations and further increasing the risk of toxicity. The interaction of erythromycin with theophylline springerlink. Theophylline is used to treat the symptoms of asthma or other lung conditions that block your airways, such as emphysema or chronic. Pdf to determine a change in theophylline pharmacokinetics during concomitant.
Pdf theophylline and antiparasitic drug interactions. Montelukast has fewer drug interactions than either zafirlukast or zileuton. Interaction between phenytoin and theophylline in healthy volunteers. Theo 24, theocron theophylline dosing, indications. Theophylline in dextrose theophylline injection, solution hospira, inc. The effect of phenytoin, 100 mg thrice daily for 3 weeks, on theophylline disposition was studied in eight healthy volunteers. This medication belongs to a class of drugs known as xanthines. In copd, lowdose theophylline is the first drug to demonstrate clear antiinflammatory effects, and thus it may even have a role in preventing progression of the disease.